15 49.0138 8.38624 1 1 4000 1 http://www.kalindamarlab.com 297

Bacterial Effector Proteins

I am broadly interested in bacterial secretion systems and secreted effector proteins in pathogenic and non-pathogenic bacteria. In particular, my future research interests are shaped by understanding the function of Type III secretion system (T3SS), Type IV secretion system (T4SS), and Type VI secretion system (T6SS) effector proteins and developing novel strategies for designing effector protein-based therapeutics. My research agenda focuses on the questions that how T3SS, T4SS, and T6SS effector proteins are important in the manipulation of the host environment for the bacterial invasion. My research strategies integrate the T3SS, T4SS, and T6SS effector proteins and host immune system to reveal the function of the effector proteins for the host-pathogen interactions. My past research investigates the characterization of T6SS and understanding the role of T6SS effector proteins in Edwardsiella ictaluri.

My plans for the future involved in identifying more novel T3SS, T4SS, and T6SS effector proteins and understanding their function for the bacterial competition or the host-pathogen interactions. I plan to focus on the effector proteins that play an essential role in inter- or intra- bacterial competitions in the microbial communities. Additionally, I have the interest to work in the area that identifies the protein domains for the T3SS, T4SS, and T6SS effector proteins to reveal the underlying properties of the effector proteins. The main motivation here is to identify novel effector protein domains on the pathogenic and non-pathogenic bacterial genomes.

© The image was taken from A systematic exploration of the interactions between bacterial effector proteins and host cell membranes.

Principle Investigator